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Right-click on dotnetfx45-full-x86-x64.exe and select "Run as Administrator." Do not simply double-click it, as restricted user accounts may fail to write to system folders.
Once you have downloaded dotnetfx45-full-x86-x64.exe, follow these steps to install it on a target machine (e.g., a Windows 7 PC that has never been updated). download dotnetfx45-full-x86-x64.exe offline installer
reg query "HKLM\SOFTWARE\Microsoft\NET Framework Setup\NDP\v4\Full" /v Release