physiology and pharmacology experiments
in virtual laboratories
almost like in the real world
- Perfect for online teaching and remote learning -
Once you have extracted the .cab file using Method 1, follow these steps to install it via the Command Prompt.
Step 1: Open Command Prompt as Administrator
Step 2: Run the DISM Command
You need to tell Windows where the .cab file is located. Assuming you copied the file to your C:\Temp folder, use the following command syntax:
DISM /Online /Add-Package /PackagePath:"C:\Path\To\Your\File\Microsoft-Windows-NetFx3-OnDemand-Package.cab"
Example: If the file is on your Desktop:
DISM /Online /Add-Package /PackagePath:"C:\Users\YourUsername\Desktop\Microsoft-Windows-NetFx3-OnDemand-Package.cab"
Step 3: Wait for Installation
Some users prefer the feature name method. It works only if the CAB is in the default Windows location, but you can specify the source:
DISM /Online /Enable-Feature /FeatureName:NetFx3 /All /LimitAccess /Source:C:\temp
Cause: DISM cannot locate the .cab file or the file is corrupted.
Solution:
Download the official Windows ISO using Microsoft’s Media Creation Tool. Mount the ISO, then navigate to X:\sources\sxs\. The microsoft-windows-netfx3-ondemand-package.cab will be inside.
This is the only safe method to obtain the .cab file manually.
Step 1: Download the Windows ISO
Step 2: Locate the CAB File
If you have mounted a Windows ISO and cannot find the specific .cab file, you can point DISM to the entire sources\sxs folder on the ISO. Windows will automatically find and install the NetFx3 components:
DISM /Online /Enable-Feature /FeatureName:NetFx3 /All /LimitAccess /Source:"D:\sources\sxs"
(Replace D: with the drive letter of your mounted ISO).
Even with the correct .cab file, you may encounter errors. Here are the most frequent issues and their solutions.
1. Error: 0x800f0954 or 0x800F081F
This usually happens if Windows Update is disabled or if the system cannot access the update servers. Using the DISM command with the local .cab file (Method above) usually solves this.
2. "The source files could not be found"
If you try to install using the "Turn Windows features on or off" menu without internet, you will see this. You must use the Command Prompt (DISM) method pointing directly to the .cab file you extracted from the ISO.
3. File Version Mismatch
Ensure the .cab file comes from the exact same version of Windows you are running.
running on all Windows platforms,
from Win 7 to Win 11, 32 bit as well as 64 bit versions
without any specific requirements (see Technical Specifications)
including platform-independent Online Versions
for experiments via the Virtual Physiology server
existing so far for SimHeart and SimVessel
with beta-versions of SimMuscle and SimNeuron
SimHeart offers a virtual laboratory for recordings of heart contractions in the Langendorff set-up in response on the most relevant transmitters and drugs, including a drug laboratory for the adjustment of the appropriate solutions.
SimVessel offers a virtual laboratory for the examination of smooth muscle contractions of vessels and the intestine.
The experiments can be done with muscle stripes, placed in an organ bath to which physiologically relevant signal substances and widely used drugs can be added. Preparing the appropriate dilutions can be trained, as in SimHeart, in a drug laboratory.
The virtual “SimMuscle” laboratory contains two nerve-muscle preparations and all the apparatus that you will need for experimentation in a simplified but quite realistic form.
When entering the lab you first need to switch on all the devices (POWER buttons). Then drag one of two already prepared nerve-muscle preparations from the Petri-dish to hang it in the suspension apparatus. This includes a mechano-electrical converter transforming changes of either the muscle force or muscle length, selectable by a toggle switch, into an electric potential. You can pre-stretch the muscle hanging one or more weights in the loop at which the muscle is fixed.
Muscle contractions are induced by current pulses delivered from a stimulation apparatus to the electrodes on which the nerve is placed. Stimuli as well as muscle contractions are displayed on a dual beam storage oscilloscope, appropriately displayed with accordingly adjusted voltage amplification and time base (via the rotary switches) and zero lines. Single or double pulses as well as trains of stimuli of selectable amplitude and intervals can be applied.
The example shows muscle contractions, here changes of the muscle length, in response to different trains of voltage pulses inducing isolated twitches, incomplete and complete tetanic contractions depending on the intervals in which the pulses are applied.
Once you have extracted the .cab file using Method 1, follow these steps to install it via the Command Prompt.
Step 1: Open Command Prompt as Administrator
Step 2: Run the DISM Command
You need to tell Windows where the .cab file is located. Assuming you copied the file to your C:\Temp folder, use the following command syntax:
DISM /Online /Add-Package /PackagePath:"C:\Path\To\Your\File\Microsoft-Windows-NetFx3-OnDemand-Package.cab"
Example: If the file is on your Desktop:
DISM /Online /Add-Package /PackagePath:"C:\Users\YourUsername\Desktop\Microsoft-Windows-NetFx3-OnDemand-Package.cab"
Step 3: Wait for Installation
Some users prefer the feature name method. It works only if the CAB is in the default Windows location, but you can specify the source:
DISM /Online /Enable-Feature /FeatureName:NetFx3 /All /LimitAccess /Source:C:\temp
Cause: DISM cannot locate the .cab file or the file is corrupted.
Solution:
Download the official Windows ISO using Microsoft’s Media Creation Tool. Mount the ISO, then navigate to X:\sources\sxs\. The microsoft-windows-netfx3-ondemand-package.cab will be inside.
This is the only safe method to obtain the .cab file manually.
Step 1: Download the Windows ISO
Step 2: Locate the CAB File
If you have mounted a Windows ISO and cannot find the specific .cab file, you can point DISM to the entire sources\sxs folder on the ISO. Windows will automatically find and install the NetFx3 components:
DISM /Online /Enable-Feature /FeatureName:NetFx3 /All /LimitAccess /Source:"D:\sources\sxs"
(Replace D: with the drive letter of your mounted ISO).
Even with the correct .cab file, you may encounter errors. Here are the most frequent issues and their solutions.
1. Error: 0x800f0954 or 0x800F081F
This usually happens if Windows Update is disabled or if the system cannot access the update servers. Using the DISM command with the local .cab file (Method above) usually solves this.
2. "The source files could not be found"
If you try to install using the "Turn Windows features on or off" menu without internet, you will see this. You must use the Command Prompt (DISM) method pointing directly to the .cab file you extracted from the ISO.
3. File Version Mismatch
Ensure the .cab file comes from the exact same version of Windows you are running.
SimNeuron offers virtual laboratories for voltage- and current-clamp experiments in an easy to overlook lab design
In fully licensed versions there is the possibility to select to which specific features of the program the students shall have access. This can be done in so-called pre-settings window which you can open from the labs via the SETTINGS button in the switch bank. In demo versions the pre-settings are fixed with most functions enabled. Step 2: Run the DISM Command You need