Microsoft+sharepoint+designer+2010+64bit+portable Today
If your portable version won't start due to "side-by-side configuration is incorrect", you need to extract the manifest file:
Run the portable with the /extract parameter (if the repacker included it), or use Resource Hacker to pull the embedded manifest and register the dependent WinSxS assemblies manually.
Let's be clear: Microsoft never released an official portable version of SharePoint Designer 2010. The "portable" concept comes from third-party repackagers who took the original MSI installer (64-bit) and used tools like VMware ThinApp, Cameyo, or Turbo Studio to convert the installation into a standalone executable. microsoft+sharepoint+designer+2010+64bit+portable
Therefore, searching for microsoft sharepoint designer 2010 64bit portable leads you into a gray area of abandonware, forum links, and potentially dangerous file-sharing sites. If your portable version won't start due to
Do not download random EXEs from torrent sites. Instead: Microsoft never compiled SPD 2010 as a native
No official 64-bit version of Microsoft SharePoint Designer 2010 was ever released by Microsoft.
Microsoft never compiled SPD 2010 as a native 64-bit application. All official downloads from MSDN, TechNet, and the Microsoft Download Center delivered a 32-bit executable.