Since the vast majority play RE6 via Steam, these are the most effective solutions.
Real-time scanning can conflict with RE6’s arc file extraction. resident evil 6 fatal error failed open file
Rename (backup) folder:
%USERPROFILE%\Documents\CAPCOM\RESIDENT EVIL 6
→ Launch game → If works, copy back save file only (not config.ini). Since the vast majority play RE6 via Steam,
If specific error mentions a file (rare), check its presence: Restart your PC
\nativePC\arc\room100.arc (missing) → reinstall that .cab from Steam.